(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride
7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride
CAS: 600734-06-3
Molecular Formula: C22H25N3O4.ClH
(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride - Names and Identifiers
(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride - Physico-chemical Properties
| Molecular Formula | C22H25N3O4.ClH |
| Molar Mass | 431.917 |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | -20°C |
| In vitro study | Delivery of Bay 65-1942 prior to ischemia significantly decreases left ventricular infarct size compared with animals receiving vehicle. Compared with sham animals, animals receiving vehicle have a significant increase in the infarct-to-area at risk (AAR) ratio (70.7±3.4 vs. 5.8±3.4%, P<0.05). This ratio is significantly reduced by treatment with Bay 65-1942 at each time point (prior to ischemia 42.7±4.1%, at reperfusion 42.7±7.5%, 2 h of reperfusion 29.4±5.2%; each group P<0.05 vs. vehicle). Animals pretreated with Bay 65-1942 (n=3) have significantly attenuated CK-MB levels compared with those animals without treatment prior to IR (14,170 ±3,219 units, P<0.05 vs. vehicle). |
| In vivo study | Inhibitors of MEK (AZD6244) and IKK (BAY 65-1942) are used at their IC 50 concentrations, as determined by a 48 hour MTS assay, which achieve sufficient inhibition of kinase activity. MYL-R cells are treated for 24 hours with AZD6244 (5 µM), BAY 65-1942 (10 µM), or a combination of these inhibitors at the same concentrations. AZD6244 and BAY 65-1942 demonstrate synergistic inhibition of cell viability at the dose combination (5 µM AZD6244+10 µM BAY 65-1942), which correlates with IC 75 (CI = 0.48±0.01). Synergism is also indicated at the IC 50 (CI = 0.56±0.09) and IC 90 (CI = 0.46±0.02) dose combinations reported by the software (CI values are the mean of three independent experiments, ± standard deviation). AZD6244 and BAY 65-1942 treatment induces 2- and 1.3-fold caspase 3/7 activation, respectively, compared to the DMSO-treated cells. Treatment with a combination of AZD6244 plus BAY 65-1942 leads to a 3.2-fold increase in caspase 3/7 activity. |
(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.315 ml | 11.576 ml | 23.153 ml |
| 5 mM | 0.463 ml | 2.315 ml | 4.631 ml |
| 10 mM | 0.232 ml | 1.158 ml | 2.315 ml |
| 5 mM | 0.046 ml | 0.232 ml | 0.463 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 7-[2-(Cyclopropylmethoxy)-6-hydroxyphenyl]-1,4-dihydro-5-[(3S)-3-piperidinyl]-2H-pyrido[2,3-d][1,3]oxazin-2-one hydrochloride Visit Supplier Webpage Request for quotation
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View History
(S)-7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(piperidin-3-yl)-1H-pyrido[2,3-d][1,3]oxazin-2(4H)-one hydrochloride
2-[6-(dimethylamino)-4-(trifluoromethyl)pyridin-2-yl]benzoic acid
(3Z)-3-[(butan-2-yloxy)imino]-1-phenyl-2,3-dihydro-1H-indol-2-one
(2Z)-2,3-dichloro-3-[(1-cyanocyclohexyl)carbamoyl]prop-2-enoic acid
N-(1-Methylethyl)-2-(phenylsulfinyl)benzamide
2-bromo-1-chloro-4-(chloromethyl)benzene
[5-(4-Nitrobenzyl)thiazol-2-yl]amine
Acetamide, N-(aminocarbonyl)-2-(2-nitrophenoxy)-
1-(2-Fluoro-5-nitrophenyl)-2,5-dimethylpyrrole
BENZOTHIAZOLE-2-CARBOXALDEHYDE
2-[6-(dimethylamino)-4-(trifluoromethyl)pyridin-2-yl]benzoic acid
(3Z)-3-[(butan-2-yloxy)imino]-1-phenyl-2,3-dihydro-1H-indol-2-one
(2Z)-2,3-dichloro-3-[(1-cyanocyclohexyl)carbamoyl]prop-2-enoic acid
N-(1-Methylethyl)-2-(phenylsulfinyl)benzamide
2-bromo-1-chloro-4-(chloromethyl)benzene
[5-(4-Nitrobenzyl)thiazol-2-yl]amine
Acetamide, N-(aminocarbonyl)-2-(2-nitrophenoxy)-
1-(2-Fluoro-5-nitrophenyl)-2,5-dimethylpyrrole
BENZOTHIAZOLE-2-CARBOXALDEHYDE